Amino acids within hypervariable region 1 of avian coronavirus IBV (Massachusetts serotype) spike glycoprotein are associated with neutralization epitopes
نویسندگان
چکیده
منابع مشابه
Evolution of avian coronavirus IBV: sequence of the matrix glycoprotein gene and intergenic region of several serotypes.
We have sequenced 200 to 240 bases of the matrix (M) glycoprotein gene of 23 strains of infectious bronchitis virus (IBV) representing the A (D207), B (D3896), C (D3128), D (D212), Massachusetts (Mass), UK11 and UK12 serotypes. The bases examined code for the external, hydrophilic region and the first membrane-embedded hydrophobic region of M, both regions comprising approximately 20 amino acid...
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S OF PAPERS 239 101 Genome sequencing and comparative analysis of avian coronavirus. M. W. Jackwood,* E. T. McKinley, J. E. Philips, and S. W. Thor, University of Georgia, Athens. Genome sequencing and comparative genomics can be used to examine past host and tissue tropism shifts to aid in identification of new variant viruses, to identify genetic differences between different pathotypes, and ...
متن کاملCharacterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein
The hypervariable region 1 (HVR1) comprising the first 27 aa of E2 glycoprotein is a target for neutralizing antibodies against hepatitis C virus (HCV), but the mechanisms of this neutralization in the cell-culture-infectious genotype 2a strain JFH1 HCV virus (HCVcc) system are unknown. Two rabbit polyclonal sera, R1020 and R140, recognizing the HVR1 of the genotype 1a isolates H77c and Glasgow...
متن کاملAmino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor.
A novel coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV), has recently been identified as the causative agent of severe acute respiratory syndrome (SARS). SARS-CoV appears similar to other coronaviruses in both virion structure and genome organization. It is known for other coronaviruses that the spike (S) glycoprotein is required for both viral attachment to permissive cel...
متن کاملSequence and Phylogenetic Analysis of Membrane (M) Gene of Infectious Bronchitis Viruses Isolated in Iran during 2014 - 2015
Background and Aims: Avian infectious bronchitis virus (IBV) has a worldwide distribution and mutations occurring in the large viral genome of IBV have led to extensive antigenic variations among IBVs. This is the first study conducted to determine the complete membrane (M) gene sequences of different Iranian IBV genotypes. Materials and Methods: The M gene of three 793/B (IBKG1,6,7), one Mass...
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ژورنال
عنوان ژورنال: Virus Research
سال: 1988
ISSN: 0168-1702
DOI: 10.1016/0168-1702(88)90039-1